A Click Chemistry‐Based Artificial Metallo‐Nuclease
نویسندگان
چکیده
A new click chemistry generated artificial metallonuclease is reported in the Research Article by Andrew Kellett et al. (e202305759). The oxidative DNA damaging properties of a polynuclear copper binding ligand called TC-Thio demonstrated. Copper-TC-Thio binds minor groove genomic and promotes damage via superoxide linked mechanism. inset picture shows ions, bound to ligand, melting into duplex filling reaction chamber with molten liquid DNA.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2023
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/anie.202310432